Is Hyaluronic Acid Still Worth Using in 2025?

By Dr Claudia Moreau | Skincare Science | The International Institute of Beauty

In the ever evolving world of skincare, few ingredients have achieved the enduring acclaim of hyaluronic acid (HA). Once hailed as the cornerstone of hydration in both topical and injectable forms, its popularity has been virtually unchallenged for over a decade. However, as we move further into 2025, many consumers and clinicians alike are asking: Is hyaluronic acid still worth using?

The short answer is yes, but with caveats. The science remains compelling, yet emerging research, product innovation, and shifting consumer expectations are changing the landscape. This article delves into the clinical evidence behind hyaluronic acid in 2025 and explores when, how, and if it still deserves a place in a modern skincare regimen.

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A Brief Refresher: What Is Hyaluronic Acid?

Hyaluronic acid is a glycosaminoglycan naturally found in the human body, particularly in connective tissues and the dermis. Its primary function is to bind and retain water up to 1,000 times its weight making it vital for maintaining hydration, skin volume, and elasticity.

Over the years, HA has been incorporated into a vast array of topical products serums, creams, masks and used extensively in aesthetic medicine, particularly dermal fillers. Its biocompatibility and immediate plumping effect have made it a go to for hydration and volume loss.

The Science: What Has Changed Since 2020?

Between 2020 and 2025, several key studies have expanded our understanding of how hyaluronic acid functions in the skin, particularly when applied topically.

1. Molecular Weight Matters More Than EverHA comes in varying molecular weights high, medium, and low. High molecular weight HA (HMW HA) remains on the surface, creating a barrier and immediate plumping effect. Low molecular weight HA (LMW HA) can penetrate more deeply, purportedly stimulating fibroblasts and increasing endogenous HA production.

   
   

   Recent research has nuanced this view. While LMW HA does appear to reach the deeper epidermal layers, it may also incite mild inflammation in certain skin types, potentially exacerbating conditions like rosacea or perioral dermatitis.

   
   

   Clinical formulations in 2025 are now more likely to combine multiple weights for a balanced effect, often pairing them with anti inflammatories such as panthenol or madecassoside.

   
   

2. Skin Microbiome InteractionsStudies from 2023 onwards have highlighted the relationship between topical HA and the skin microbiome. It is now understood that some forms of HA can act as prebiotics, supporting a healthy microbial balance.

   
   

   However, overuse particularly in occlusive formulations may disrupt this balance, leading to issues such as fungal acne (Malassezia folliculitis).

3. Hydration Isn’t Always EnoughAs the skin barrier research has advanced, it’s become increasingly clear that hydration alone does not equate to skin health.

   
   

   Ingredients such as ceramides, fatty acids, and niacinamide are now viewed as essential complements to HA, ensuring that hydration is retained and that the barrier is properly fortified.

   
   

Is HA Still Clinically Effective in 2025?

Yes but its efficacy is context dependent. A 2024 meta analysis in the British Journal of Dermatology reviewed 32 clinical trials and confirmed that topical HA, particularly in multi weight formulations, improves hydration and superficial wrinkling within two to six weeks of use. However, the study also noted diminishing returns when HA is used in isolation, particularly in mature or barrier compromised skin.

Meanwhile, injectable forms of HA remain gold standard in aesthetic dermatology. Advances in cross linking technology have allowed for longer lasting fillers with more natural integration, particularly in dynamic areas such as the nasolabial folds and tear troughs. However, increased scrutiny on filler fatigue and tissue integrity has led practitioners to adopt more conservative approaches, reserving injectables for targeted, minimal interventions.

What About “Hyaluronic Acid Fatigue”?

A growing concern among consumers is the idea of “hyaluronic acid fatigue” the perception that the skin becomes reliant on or unresponsive to HA over time. While there is no formal clinical evidence to support this notion, anecdotal reports suggest that prolonged use of HA without supporting lipids or antioxidants may lead to trans epidermal water loss (TEWL), particularly in dry climates.

The solution is not to abandon HA, but to use it wisely: apply on damp skin, seal with an occlusive or emollient, and pair with barrier repair ingredients. In clinical settings, this tailored approach is proving more effective than simply layering HA based products indiscriminately.

New Generation Formulations: What’s Emerging?

In 2025, innovation in HA delivery systems is driving a new generation of products that extend beyond simple hydration:

• Encapsulated HA: Liposomal or nano encapsulated HA is gaining traction, enabling deeper delivery and prolonged release. These systems offer improved stability and reduced irritation.

  
  

• HA Precursors and Boosters: Instead of applying HA directly, some formulas now use N acetyl glucosamine and other precursors to stimulate the skin’s own production of HA.

  
  

• HA with Peptides and Growth Factors: Combination products that include signal peptides or epidermal growth factors (EGF) show synergistic effects, enhancing both hydration and dermal repair.

  
  

These innovations suggest a shift from HA as a standalone hero ingredient to one part of a more complex, synergistic formulation strategy.

Conclusion: Still Worthwhile, But No Longer a Miracle

In 2025, hyaluronic acid remains a v aluable component of a comprehensive skincare routine, particularly for hydration and early signs of ageing. However, the industry and informed consumers have moved beyond viewing it as a cure all. Its best results are seen when used judiciously within well formulated products, combined with barrier supporting ingredients, and personalised to individual skin needs.

As always, the key lies not in the ingredient itself, but in the formulation, delivery, and application strategy. In the hands of a knowledgeable professional or an educated consumer, hyaluronic acid remains not only relevant, but indispensable.